NY countered with an 8-3 triumph Saturday afternoon.
At the rate things were going, a few more innings could have left NY without enough players to keep playing anyway.
Add to that the unavailability of relievers Aroldis Chapman, Dellin Betances, Chad Green and Tommy Kahnle - all of whom pitched in Friday's marathon - and Saturday's game had all the elements of a thoroughly unpleasant afternoon for the Yankees.
After working quickly through the first two innings, Gray struggled with command and Machado tied the game by lifting a 2-0 breaking ball just inside fair territory in left field for a double.
Sonny Gray (1-0) gave the Yankees some distance by allowing three runs and four hits in six innings.
Dating back to Tuesday in Houston, Orioles starters have allowed just seven runs in 22 innings, for an ERA of 2.86.More news: Trump conjures a new immigrant rape epidemic
Throughout his outing, Sabathia was touched up by the Orioles, allowing three home runs.
However, if injuries continue to plague him and he misses an extended period of time the Yankees rotation takes a big hit. He is 0-9 with an 8.32 ERA since May 7.
Baltimore has won the first two games after getting a grand slam from Pedro Alvarez in the 14th inning of Friday's 7-3 win. The Yankees improved to 5-4 with the win.
Miguel Andujar drove in the go-ahead run in the sixth inning with a sacrifice fly after Aaron Judge had tied the game an inning prior with an RBI groundout.
The Yankees took a 2-0 lead when Gardner's single deflected off first baseman Chris Davis' glove and into right field. He was removed after four innings of what would become a 14-inning game because of pain in his hip.
Jordan Montgomery makes his second start for the Yankees in this contest. He walked four and didn't record a strikeout.More news: Is Cardi B Trying To Hide Her Baby Bump Amid Rumored Pregnancy?
Gray will be making his 13th start with the Yankees and Sunday was the fifth time he did not complete six innings. He walked four and didn't strike out any. NY led 4-1 when he left: Tampa Bay rallied to tie the game before the Yankees rolled to an 11-4 win. Gray finished the season 10-12 overall with a 3.55 ERA and a 1.21 WHIP.
Either Luis Cessa or Domingo German will take CC's next turn in the rotation and neither of those options has yet to really show that they can succeed at the big league level. The additions of Cobb and another right-hander, Andrew Cashner makes things more comfortable for Tillman. Throw in the hassle of New York City traffic, and the manager wouldn't have had much time for sleep if he had traveled home. Baltimore is still without closer Zach Britton, who likely won't be ready until June after having surgery for a torn Achilles.
In addition to Sabathia being placed on the disabled list, so was his teammate Brandon Drury.
That appears to be the trend for the banged-up Yankees, who also lost catcher Gary Sanchez and infielders Brandon Drury and Tyler Wade during the game.
The New York Yankees are officially banged up. It will be important for today's starters to go deep into the game.
- Judge jumped at the wall and took away a homer from Joseph for the final out of the 13th - in almost the exact spot where he robbed Cleveland's Francisco Lindor in Game 3 of last year's AL Division Series.More news: Vernon Philander delights skipper Faf Du Plessis as South Africa crush Australia