Sanders says he expects to spend a great deal of time in Vermont, but added he will campaign for progressives across the country as well.
In a statement issued by his campaign, Sanders - who is also among the list of possible contenders for the Democratic presidential nomination in 2020, having been defeated by Hillary Clinton in the last campaign - said it had been an honor to serve the people of Vermont, but more remained to be done.
"Over the last two terms I have been one of the leaders in the Senate in addressing some of the major crises facing Vermont and the nation", said Sanders, I-Vermont.More news: Trump Demands DOJ Probe of Federal Bureau of Investigation
"I happen to believe - and I think Vermonters have heard me say this for a while - that we're in a pivotal moment in American history", said Sanders.
Sanders' 2018 reelection campaign will begin in June.
Sanders, who caucuses with the Democrats in the Senate, claimed that a majority of the American people now support those ideas, including an "overwhelming percentage of Democrats".More news: Abramovich faces wait for United Kingdom visa
These include proposals to ensure universal access to health care, raise the minimum wage, provide free college tuition and implement a massive public works initiative. He plans to maintain it during a third term in the U.S. Senate. "I think it is fair to say that from an ideological point of view, what the Democratic Party should stand for, we have kind of won that debate".
In March, Sanders helped launch what purports to be a global peace movement on the anniversary of the Iraq War, which he said precipitated much of the chaos in the Middle East. Bernie Sanders (I-Vt.) attacked the Democratic National Committee (DNC), arguing that national Democrats are making the same mistakes that led to the Republican wave year of 2014.More news: Republican infighting over immigration spills over with farm bill collapse