Mrs Trump is expected to stay in hospital for the rest of the week.
The anti-bullying advocate's hospitalisation comes on the heels of wrapping a busy month at her home at 1600 Pennsylvania Avenue.
The White House said she went through an embolization procedure for a "benign" condition.
Former First Lady Rosalynn Carter wife of the 39th President of the US Jimmy Carter underwent a treatment of benign breast lump in 1977.
Trump was initially hesitant to shift base from NY to Washington DC since it would mean midyear changing of school of Barron, her son with US President Donald Trump.More news: Monster black hole discovered growing very fast - far, far away
Last month, she took the lead in planning the first state dinner of the Trump administration, welcoming French President Emmanuel Macron and his wife, Brigitte, to celebrate almost 250 years of U.S.
The Internet has gone wild with speculation that Melania Trump is miserable in her role as First Lady. The hat set the internet ablaze, with references and comparisons to Beyoncé, the suffragette movement and even television character Olivia Pope of "Scandal".
Last week the first lady announced an anti-cyberbullying initiative called "Be Best", which is aimed at cyberbullying and other issues affecting children.
Punch reports that the procedure comes a week after Trump launched her official platform, dubbed "Be Best" - an awareness campaign focused on children's well-being, social media use and opioid abuse. The latter caused a firestorm of controversy because it encompasses cyberbullying, a tactic that Melania Trump's husband, the President, has often been accused of fueling.More news: Senators face choice on CIA director nominee ahead of key votes
The White House has not offered any additional details on the first lady's condition. Dr. Craig Rogers, the head of Henry Ford Hospital's Renal Surgery said she likely had some painful symptoms. But I don't know.
The first lady, 48, will likely remain hospitalized "for the duration of the week", the statement added.
She was last seen in public on Wednesday at a White House event to honour military mothers and spouses for Mother's Day.
"She's become a very, very popular first lady".More news: Huawei's Honor 10 flagship smartphone is finally here