The ceremony took place at St George's Chapel, Windsor Castle, under a brilliant blue sky, which is especially good news for the royal onlookers who staked their spot as early as yesterday.
The weather was balmy and clear, bathing the ancient stones of Windsor Castle in a handsome spring light. Police armed with semi-automatic weapons patrolled the streets and monitored from nearby roofs. Winfrey opted for a light pink frock paired with a feathered hat - a last-minute switch after realising yesterday that her original dress was too white, friend Gayle King said on CBS.
"They're so involved and so wanting to help other people - minorities and charities of all sorts... and I think they'll continue to do more and more as a team", said Toni MacKenzie said.
Outside the castle, thousands of fans crammed the streets of Windsor. "Real power. Power to change the world", the African-American preacher intoned.
The hour-long ceremony begins at 1100 GMT.
Markle rode with her mother Doria Ragland in a vintage Rolls Royce from the Cliveden House Hotel, about 10 miles from Windsor Castle.
Surrounded by page boys and girls, Markle can't stop smiling until she gets to a waiting Harry.
British reserve crisscrossed with American verve in a service that broke molds and created new ones. Prince Charles, Harry's dad, walked Meghan part of the way down the aisle.More news: Dead in Texas School Shooting Identified
Markle seemed poised and confident as she delivered her vows without so much as a quiver in her voice.
His impassioned preaching style was a marked departure from the usually conservative tone of a British royal wedding.
"An American in the royal family, isn't that so exciting?" she said.
Archbishop of Canterbury Justin Welby declared them husband and wife - sparking huge cheers from crowds outside the church, watching on big screens.
She was followed by the Most Reverend Michael Curry, who is the first black presiding bishop of the Episcopal church in the United States.
After the ceremony, the newlyweds are expected to greet some of the 1,200 members of the public specially invited into the grounds of the castle before setting off on a carriage procession through Windsor.
In a private evening reception held at Frogmore House, 200 chosen guests let their hair down with the alcohol flowing.More news: Washington Sanctions Venezuela's Cabello For Drug Trafficking, Florida Companies Hit
If his mother, Diana, had been the people's princess then Harry has certainly become the people's prince, and the crowd made it clear that this was most definitely the people's wedding.
Last year, he spoke openly of his emotional torment following the 1997 death of his mother in a Paris auto crash. "This woman will be able to handle anything, she's just incredible".
The couple met on a blind date in July 2016 and had a whirlwind romance, criss-crossing the Atlantic as she continued filming "Suits" in Toronto.
From the couple getting the giggles at the altar to Meghan's mom becoming emotional while taking in her daughter's big day, the ceremony was full of familiar moments.
"You look wonderful", Harry told his bride as she arrived.
Harry's gilded upbringing is in stark contrast with Markle's.
After a number of minor roles in films and on TV, she won the role as Rachel Zane in "Suits". "It's ideal for her and for the occasion they are celebrating".
The intense spotlight on her father this week was indicative of the limelight she now faces. The entire congregation stood to sing "God Save the Queen", capping the event.More news: Tata Steel completes Bhushan Steel acquisition
The queen hosted a lunchtime reception at the castle, where Elton John performed to guests eating canapes including Scottish langoustines, English asparagus and Windsor lamb. Many outlets have heralded her walk as a feminist statement.