The eruption of the 3,763-metre Volcan de Fuego - meaning "volcano of fire" in Spanish - was the most powerful in recent years, according to the National Institute of Seismology, Volcanology, Meteorology and Hydrology (Insivumeh).
"It's a river of lava that overflowed its banks and affected the Rodeo village". Three bodies lay partially buried in ash-colored debris from the volcano, which lies about 27 miles from Guatemala City.
A auto is partially covered with ash after Guatemala's Fuego volcano erupted violently, in Guatemala City, Guatemala June 3, 2018.
Dozens of videos were popping up on social media and local TV, depicting the extent of devastation.More news: Warriors vs. Cavaliers, Game 2
The dead included a Conred employee and at least three children, officials said.
"It is important to remain calm because the Fuego volcano erupts throughout the year", said David de Leon, spokesman for the National Disaster Prevention Authority.
Among the fatalities four people were killed when lava set a house on fire in El Rodeo village, Cabanas said.
The seventh victim of the frightening natural disaster was found in the streets of El Rodeo before they later died in an ambulance.More news: Aussie Smith surges to lead in weather-hit US Women's Open
Guatemala's disaster agency said 3,100 people had evacuated nearby communities, and ash fall from the eruption was affecting an area with about 1.7 million of country's 15 million or so people.
Ash fell on the Guatemala City area as well as the departments of Sacatepequez, Chimaltenango and Escuintla, which are in south-central Guatemala around the volcano.
It is the second time the volcano has erupted this year, setting off loud explosions and spewing ash almost four miles into the sky. The explosion rained soot over the popular tourist destination and other villages in the Sacatepéquez department, covering them in ash. Guatemala's nearby airport, La Aurora International, shut down due to the eruption.More news: Microsoft is Planning to buy GitHub at $2 Billion