Scientists create ‘artificial ovary’ to help women left infertile from cancer therapy

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News on the fertility front may offer hope in the future for women who have to undergo chemotherapy or radiation during cancer treatment.

He said the technique was "likely to develop into something that will be potentially useful", but said further research was needed to prove it will work in humans.

Nick Macklon, medical director at London Women's Clinic, said that while there was a low risk of contracting cancer from frozen ovarian tissue, it is a danger that doctors take seriously. Pors, on Monday, would be addressing and telling in a yearly meeting of the European Society of Human Reproduction and Embryology at Barcelona, about the method with which the team implanted the artificial ovary.

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Researchers from the Rigshospitalet in Copenhagen, Denmark, report today that they have for the first time isolated and grown human follicles to a point of "biofunctionality" on a bioengineered ovarian scaffold made of "decellularised" ovarian tissue. One of the options of preserving fertility is freezing the eggs after their removal prior to cancer therapy. This new study attempts to use the ovarian tissues outside of the body in the labs rather than risk reintroducing the tissues along with the cancer. To make one, they used chemicals to strip donated ovarian tissue of all of its cells, including any lurking cancer cells.

But they said it might have advantages over other fertility treatments.

The Danish experts suggest that a prototype of the artificial ovary. To compensate for the effects of treatment of cancer patient, as a rule, transplanted previously frozen ovarian tissue. The researchers seeded this structural matrix with early-stage follicles. Which were collected from cancer patients. Brison, who was not involved in the study, noted that the use of decellularized scaffolds is common in regenerative medicine, where tissues derived from stem cells are transplanted back into patients.

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A review published this year by Pors and her co-authors reported that a total of 318 women worldwide had undergone ovarian tissue transfers, with nine receiving a diagnosis of cancer afterward (in all cases not directly caused by the procedure).

This artificial ovary was then transplanted into mice, where it was able to support the survival and growth of the ovarian cells.

Stuart Lavery, a consultant gynecologist and reproductive surgeon at Imperial College Healthcare NHS Trust, said: "The beauty of this is that numerous women who are having ovarian grafts can go and get pregnant naturally, and don't need to go through IVF".

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