Like previous year, Federer opted to skip the entire clay court season to be fresh for a grass court campaign and another run at Wimbledon, and it looks like the move may have paid dividends.
Top seed Federer admitted before the match that he can still get nervous walking out on to Centre Court but he was at his free-flowing best against Lajovic who was little more than a prop in Federer's magic show.
Federer was pushed to a tie-break in the opening set when he met the same player in the second round a year ago - but he needed just 20 minutes to hit the front this time around.More news: Willian finally speaks on Barcelona interest
Federer had continued to wear Nike without a deal, but for his opening news conference at Wimbledon, he wore an unbranded jacket.
"I felt very good from the start which is nice", Federer said on court. "When I was about to break the record, I thought, 'wow, I'm going to beat Federer at something, ' which is a lot already", Lopez said.
After just 20 minutes to complete the first set, Federer went on to fire 35 winners past Lajovic, breaking serve five times, setting up a second round encounter against either Lukas Lacko of Slovakia or French qualifier Benjamin Bonzi.
Forbes reports that Federer earned roughly $150 million from Nike over the past 20 years.More news: Wimbledon 2018: Johanna Konta's advice to smash it at tennis
Venus then led 3-1 in the tie-break but lost six consecutive points to concede the first set 6-7 in 70 minutes.
He also made the last eight at the US Open in 2015. It's a long-awaited return for American player Serena Williams, who hasn't competed on the grass court since 2016, after she took time off for the birth of her daughter, Alexis Olympia Ohanian. She gave birth to a daughter last September, and this will be the fourth tournament of her comeback.More news: Twitter goes wild for viral thread documenting budding in-flight romance