The death toll from Tuesday's blast soared overnight.
A suicide bomber in Afghanistan killed at least 68 people and wounded more than 100 others at a demonstration on Tuesday on the highway between the eastern city of Jalalabad and the main border crossing into neighbouring Pakistan, officials said.
"The majority of civilian casualties occurred in the Mohmandara district of Nangarhar when a suicide attacker detonated his explosives among a crowd which had gathered to demonstrate against an Afghan Local Police commander".
It's not clear what the protest was about, nor who carried out the attack. "At least 20 civilians were killed and more than 60 injured", UNAMA said.More news: Cardinal accused of covering up sex abuse to meet with pope
The attack came hours after smaller bombs targeted at least three schools in and around Jalalabad, killing a boy and wounding four people.
The blast also left 165 people wounded according to provincial governor spokesman Ataullah Khogyani.
There were no claims of responsibility for the attacks in Jalalabad, where nearly all recent bombings and militant raids against civilian and educational facilities have been claimed by Islamic State. The Taliban has denied involvement.
The violence follows recent diplomatic efforts to end the lengthy war between the Afghan government and the Taliban.More news: Packers taking it day by day with Aaron Rodgers
"We went with other boys to see what had happened after we heard an explosion near the girls' school", 12-year-old Elyas told the agency from his hospital bed.
Nangarhar, one of the main strongholds of Islamic State militant fighters since early 2015, has been one of the most volatile regions this year, with a string of suicide bombings and attacks on its capital, Jalalabad.
"Another explosion hit us and I was wounded (in the leg)".
The United Nations Assistance Mission in Afghanistan (UNAMA) condemned the attack in a statement and said it was voicing its mounting concern at the pattern of attacks targeting civilians and schools.More news: $1 million pledged against Susan Collins if she backs Brett Kavanaugh