"And I agree, it's different from an agenda that's much different from ours, and it's certainly not your agenda, that I can tell you", he said.
Vice President Pence denied being the senior administration official who wrote an anonymous New York Times op-ed criticizing President Donald Trump - following online speculation that a clue in the piece may have pointed to him.
"Does the so-called "Senior Administration Official" really exist, or is it just the Failing New York Times with another phoney source?"
Despite facing intense criticism for his Christian beliefs, Pence said the USA remains a "nation of faith", adding, "We'll respect the beliefs and convictions of every American, but I'm just very confident that, as we go forward and serve alongside this president, that there are an bad lot of people across this country that share our faith and appreciate where we stand".More news: Plane from Dubai quarantined at NYC airport after passengers fall ill
Trump said that he expected to be president for over six years but that the New York Times and the rest of the "phony media outlets" would fail after he left.
Some say Mr Pence is also likely to be the author because as vice-president Mr Trump can't fire him. "But we believe our first duty is to this country, and the president continues to act in a manner that is detrimental to the health of our republic".
The result, the official writes, has been a "two-track presidency" in which Trump's own worldview - uttered both in public and private - diverges from some key actions taken by the administration, like those involving additional sanctions against Russian Federation.
Journalists, conspiracy theorists, politicians from both sides of politics - and even the president himself - have begun speculating on who the "senior official in the Trump administration" may be.More news: Kim Kardashian meeting with Pres. Trump on prison reform
The writer also alleged "there were early whispers within the cabinet of invoking the 25th Amendment" because of the "instability" witnessed in the president.
While the author praises the Trump administration's accomplishment, he or she argues the following.
Vice President Pence arrives to speak at a National Day of Prayer event in the Rose Garden of the White House in May.
The individual behind this piece has chosen to deceive, rather than support, the duly elected President of the United States. "This coward should do the right thing and resign".More news: BBC presenter Rachael Bland dies at 40 after cancer battle
In this case, The Times said it granted anonymity "at the request of the author" because the person's job "would be jeopardized by its disclosure".