Ahead of the vote, hundreds of people protested against Mr Kavanaugh's nomination at the US Capitol in Washington.
Acrimonious to the end, the battle featured a climactic roll call that was interrupted several times by protesters in the Senate galleries before Capitol Police removed them.
The Women's March tweeted this image showing U.S. Senator Susan Collins (R-Maine) after she announced Friday afternoon she would vote yes on U.S. Supreme Court nominee Brett Kavanaugh.
Trump watched the confirmation vote while flying on Air Force One to a political rally in Kansas, viewing the vote on large-screen television tuned to Fox News in a wood-paneled cabin. Richard Blumenthal, D-Conn. and Elizabeth Warren, D-Mass., the latter of whom he referred to as Pocahontas, saying that he had "more Indian blood in me" than she did, "and I've got none". Kavanaugh was confirmed Saturday 50-48.
In a chamber where Republicans hold the narrowest of majorities, all senators voted in accordance with party lines, with the exception of Democrat Joe Manchin of West Virginia, who endorsed Kavanaugh, and Alaska Republican Lisa Murkowski, who voted against.
The announcements by Republican Susan Collins of ME and Democrat Joe Manchin of West Virginia ended most of the suspense over a political battle that has transfixed the nation - though die-hard Democrats insisted on arguing through the night to a mostly empty Senate chamber.More news: NASA denies hole on Space Station was confirmed to be deliberate
While the "cloture" vote is just a procedural step, it's the first time the full Senate has voted on Kavanaugh.
"I think it will go down as a sad day for her because he's going to become a great Supreme Court justice", Trump said of Murkowski.
There are no shortage of cases that Kavanaugh could wind up hearing on the Supreme Court where questions about his political preferences would arise.
"Just imagine the devastation they would cause if they ever obtain the power they so desperately want and crave", Trump said.
Drew Angerer/Getty ImagesProtestors rally against Supreme Court nominee Judge Brett Kavanaugh in the atrium of the Hart Senate Office Building on Thursday. Both he and Collins attempted to express a belief that Dr. Blasey Ford was assaulted, but not by Kavanaugh.
The allegations led to Kavanaugh and his accuser, Christine Blasey Ford, testifying before the Senate Judiciary Committee during an epic hearing. "But I think it will become a shorthand, at least on our side, for a double standard", said Sen.
Kavanaugh could choose to recuse himself from cases where his vote could be seen as tainted by the promise he made in his testimony about those working against him on behalf of the Clintons.More news: Senators Collins, Manchin back Kavanaugh, paving way for confirmation
President Donald Trump's nomination of Kavanaugh came under intense scrutiny after multiple women came forward to accuse the 53-year-old judge of sexual assault or sexual misconduct.
Kavanaugh has denied all allegations against him.
The protest comes as Kavanaugh is preparing to be sworn in by Chief Justice John Roberts and retired Justice Anthony Kennedy.
Liberals fear that by solidifying the conservative majority, the articulate judge could overturn or restrict a 1973 verdict banning state and federal regulations criminalising or restricting abortion, which the right-wing supporters of Trump want.
"We're very honored that he was able to withstand this disgusting, terrible attack by the Democrats".
He spoke of "intimidation by the mob" and said the Senate vote should be one "to turn away from darkness". "I believe we're dealing with issues right now that are bigger than the nominee, and how we ensure fairness and how our legislative and judicial branch can continue to be respected".More news: Mark Lawrenson states his prediction for Liverpool FC v Man City