The loss, which was their first defeat at the Mendizorroza stadium in almost 90 years, also marked the fourth consecutive game in which they have failed to score.
However, there is one fixture lying on the murky horizon which could signal the end for Lopetegui; Madrid travel to the Camp Nou on 28 October and a heavy defeat could see Los Blancos looking for a new face in the dugout. "But we will be judged by what we achieve by the end of the season".More news: Trio win Nobel Chemistry Prize for 'a revolution in evolution'
Ramos also said the players should take responsibility for the defeat and now was not the time to look for scapegoats.
Lopetegui has only been in the job since July after he replaced Zinedine Zidane, but following something of a honeymoon period, he really has hit work cut out. "We are the first people that need to do more to improve and we're trying to do that". It's not fair to point the blame at anyone, we're all conscious of the reality.
"We know that it is not a good time and in the worst case we are three points away from the top [if Barcelona beat Valencia on Sunday]".More news: Merkel in Israel says Iran must not obtain nuclear arms
Lopetegui confirmed Bale and Benzema were taken off due to injuries, in what could be further blows for his struggling team. "Today we had some good chances but the injuries to Bale and Benzema punished us a lot", he added.
Lopetegui says "the injuries to Karim and Gareth greatly limited what we could do".
"Logically, we are disappointed".More news: Killed In Upstate New York Limo Crash