As the senators voted, protesters in the Senate gallery screamed, "I do not consent", and, "shame", forcing Vice President Mike Pence, who was presiding over the chamber, to repeatedly call for order.
Kavanaugh moved past a key hurdle during a procedural vote in the Senate Friday that advanced his confirmation to a final vote set for Saturday.
Two other women accused him in the media of sexual misconduct in the 1980s. "Truly, Judge Kavanaugh's confirmation is a low moment for the Senate, for the court, for the country". Protesters began swarming Capitol Hill, creating a tense, confrontational atmosphere that put Capitol Police on edge. "Vote them out!" and carried signs including, "I am a survivor, not a troublemaker!" GOP operatives say they're also seeing renewed Republican interest in states like Wisconsin, where Democratic candidates for both Senate and governor have been polling strong.
Donald Trump was quick to offer praise, tweeting: "I applaud and congratulate the US Senate for confirming our GREAT NOMINEE".
Repeatedly during the Senate debate, Republicans accused Democrats of staging a "smear" campaign against Kavanaugh to prevent a conservative becoming a Supreme Court justice.
"I think for many who have experienced sexual abuse or sexual assault, it's hurtful", added another protester, Heather Harrington.More news: Lopetegui confirms Bale, Benzema injuries
Kavanaugh's nomination as a replacement for retiring justice Anthony Kennedy was controversial from the start - but the initial focus was exclusively on the conservative views held by the married father of two.
Trump, flying to Kansas for a political rally, flashed a thumbs-up gesture when the tally was announced and praised Kavanaugh for being "able to withstand this disgusting, terrible attack by the Democrats".
The brutal hearing sparked a supplemental Federal Bureau of Investigation dive into Kavanaugh's background and a week-long delay of the Senate vote.
Republicans control the Senate by a meagre 51-49 margin, and announcements of support Friday from Republicans Jeff Flake of Arizona and Susan Collins of ME, along with Democrat Joe Manchin of West Virginia, locked in the needed votes.
The White House has said he will swiftly be sworn in.
Susan Collins is followed by members of the media as she walks to the Capitol before a vote to advance Brett Kavanaugh's nomination to the Supreme Court.More news: India to keep buying Iranian oil despite US sanctions
It drew the line under a bruising nomination process defined by harrowing testimony from a woman who says Kavanaugh tried to rape her when they were teenagers - and by his fiery rebuttal.
US Senate Republican leader Mitch McConnell told Reuters yesterday that the political brawl over Supreme Court nominee Brett Kavanaugh's confirmation will help Republicans retain control of the Senate, calling it a "seminal event" leading into the November elections. While he overcame accusations of sexual harassment to win confirmation, a backlash ushered in a wave of female lawmakers.
Trump spoke to reporters on the White House lawn.
"When you blocked Merrick Garland's nomination from President Obama, you basically said that we don't do this in a presidential election year and that we wait until the election and then whoever the people choose, they get to pick the Supreme Court nominee".
"This is one of the reasons I chose him is because there is no one with a squeaky clean past like Brett Kavanaugh".
"I have to tell you, it's really wonderful to be back home in Maine", Collins said at the outset of her remarks, a likely allusion to the flurry of attention and - according to her office, threats - directed her way.More news: James Maddison, Jadon Sancho and Mason Mount named in England squad