He has the potential of a second-round meeting against wildcard Jo-Wilfried Tsonga with a potential quarter-final showdown against Kei Nishikori.
Defending champion Wozniacki, who broke through for her maiden Grand Slam title with victory over Halep in last year's final, is in line to face former victor Maria Sharapova in a mouth-watering third round showdown.
Aiming for a 21st Grand Slam trophy and a 100th career singles title, Federer will open against Denis Istomin.More news: Migrant ordeal comes to an end: Stranded migrants finally land in Malta
No. 4 Alexander Zverev is in the same half and looms in the semifinals if both players advance that far. But being so close, I'll give it a go.
Murray won only two games in an incomplete practice match with Djokovic at Melbourne Park, showing signs he's still not fully fit after spending most of the last 18 months off the tour.
Nadal will meet Australian wild card James Duckworth in his opening clash, with Kevin Anderson, John Isner and Grigor Dimitrov all in his quarter of the draw. If it would happen defending this title, I would gladly accept it.
A highlight first-round clash will see Australia's unseeded Nick Kyrgios up against Canada's big-serving 16th seed Milos Raonic, with the victor facing either Stan Wawrinka or Ernests Gulbis. Halep has a tough opening encounter against Kaia Kanepi and a possible third rounder against Venus Williams.More news: Bayern Confirm They Want To Sign Chelsea Attacker
Second-seeded Angelique Kerber, who won the Australian and U.S. Opens in 2016 and added the Wimbledon title previous year, is in the same half as Wozniacki and has 2017 U.S. Open champion Sloane Stephens in her quarter.
The draw for the first Grand Slam of the season was made on Thursday and the top seeds could face some early tests of their credentials when play gets underway in Melbourne on Monday.
Asked if he ever doubted about his comeback, Wawrinka - who underwent a double surgery in August 2017 - said: 'I did think a few times that I may not be able to come back to my old self, old level. Not just physically, but also mentally, to see that I could beat Grigor Dimitrov twice, he was top-10 at that time.More news: Iran confirms it has detained US navy veteran Michael White