Alex de Minaur, the only Australian men's seed in the draw at number 27, opens against Pedro Sousa, while other prominent first-round matchups for the locals include John Millman against Federico Delbonis, and Nick Kyrgios in a mouth-watering encounter against big-serving Canadian Milos Raonic, the 16th seed.
Aiming for a third consecutive Australian championship, a 21st Grand Slam crown and a 100th career singles title, Federer will open against Denis Istomin.More news: Jurgen Klopp blames windy conditions for Liverpool's FA Cup defeat at Wolves
The draw for the first grand slam of the year took place on Thursday, where the likes of Federer, Djokovic and Rafael Nadal all learned what their potential path to the trophy would look like.
Eighth-seeded Kei Nishikori, who opened the season with a title in Brisbane, is a potential quarterfinal rival and No. 4 Alexander Zverev looms as a semifinal opponent if both players advance that far.
Murray opens against No. 22-seeded Roberto Bautista Agut.More news: New concession on backstop following furious row over Brexit vote
In an interview to The Times of India, the three-time Grand Slam victor Stan Wawrinka commented on the Big Three's dominance.
"I can't believe it's been a year already", Dane Wozniacki said at the draw ceremony.More news: R. Kelly under Investigation following Lifetime's Documentary
Second-seeded Angelique Kerber, who won the Australian and U.S. Opens in 2016 and added the Wimbledon title previous year, is in the same half as Wozniacki and has 2017 U.S. Open champion Sloane Stephens in her quarter.