According to a 911 call made by someone in the Cali home, the crime kingpin was also run over before he was shot, though the Daily News police sources say that claim is still under investigation.
"There were like six shots, and then there were three more", one witness told the Daily News.
Police added he was taken to Staten Island University North hospital, where he was pronounced dead.More news: Taylor Swift Drags All Her Hates During iHeartRadio Speech
It is unclear who killed Cali, who reportedly became the head of the crime organization in 2015.
Castellano, the Gambino family head at that time, was shot in the street on Manhattan's East Side while on trial for conspiracy to commit murder, among other charges. They remain powerful players in the black market, however, in loan sharking, gambling, prostitution and the drug trade, according to law enforcement.
New York Mob boss Francesco "Franky Boy" Cali was taken off the board Wednesday night in a hit reminiscent of an underworld greatest hits package.
Cali is the first mob boss murdered in the Big Apple since 1985, when then-Gambino boss Paul Castellano was gunned down at Sparks steakhouse in Midtown on the orders of John Gotti.More news: Vietnamese woman loses bid for release
Cali's only mob-related criminal conviction came a decade ago, when he pleaded guilty in an extortion scheme involving a failed attempt to build a Nascar track on Staten Island. He was sentenced to life in prison and died of cancer in 2002.
The Genovese, Gambino, Lucchese, Colombo and Bonanno mafia families are believed to have controlled organised crime in NY for decades.
In October, reputed Bonanno associate Sylvester Zottola was fatally shot while waiting for a cup of coffee at a McDonald's drive-thru in the Bronx.
The Todt Hill neighborhood is known for its mafia history.More news: US Prepares to Bar Entry of International Criminal Court Investigators
Since Gotti's downfall, the Gambinos - and other mafia families - have lost much of the power they once had over politicians, judges and labor unions.