United's tie against Barcelona means interim manager Ole Gunnar Solskjær will enjoy another trip to the Nou Camp, where he scored the victor in their 1999 Champions League final win over Bayern Munich.
The draw sees caretaker boss Solskjaer return to the Nou Camp 20 years on from scoring an injury-time victor there in the 1999 Champions League final. "He's kept nine [clean sheets] in the last 11 games, or something like that, in the FA Cup so that's fantastic".
Tickets for the Wolves game are rarer than hens' teeth, and 4,500 travelling fans (14,500 season ticket holders applied for a ticket) will be fortunate enough to be at the game. "We are looking forward to this one".
Don Goodman of Wolves beats Leeds goalkeeper Nigel Martyn to score the only goal as Wolves beat Leeds in the FA Cup Quarter Final
The Gunners hoisted themselves above Solskjaer's side and into fourth place in the Premier League table in the race to secure a Champions League spot.
Solskjaer has shown a desire to give the club's youngsters opportunities in the first-team since his appointment as interim manager in December. The away section is on the top tier of football's tallest stadium and there are nets in front of it, but what a prospect.
So they will now host the first meeting against Barcelona. We're off to the Nou Camp again.More news: Ex-Tottenham star Poyet: Bale told me he's happy at Real Madrid
United can learn from the previous round against Paris Saint-Germain, both on and off the field.
United were originally drawn to play at Barcelona in the first leg, which would have given them the safety net of playing the decisive return at Old Trafford.
Unlike their treble-winning 1999 campaign, Manchester United are not in contention in the Premier League title race - though they do remain in the FA Cup and face Wolves on Saturday at 19:55 GMT, live on BBC One and the BBC Sport website.More news: Trump issues first veto to protect border order
But the fixture has been reversed so that the Spanish giants will be away for the first match. Manchester United have won 10 FA Cup trophies since Wolves last cup win.
"There are so many variables and these games will be decided by margins".
Hammering Lyon on Wednesday saw Barca, who are now unbeaten in 30 home European games, reach the last eight for the 12th successive year.More news: I'm not old enough to vote, but I'm marching against climate change
British Transport Police are deploying extra patrols at Wolverhampton station and on trains to and from Manchester in anticipation of Manchester United arriving at Molineux on Saturday.