Ajax will play Juventus, first in Amsterdam on April 10, in a rematch of two previous finals.
Manchester City are most likely to be crowned the winners of the Champions League this season. But can they pull off another shock by eliminating Juventus, and Cristiano Ronaldo, from the competition?
Will Guardiola lead City to the Champions League crown this season? They're now +28 units on the season while draws have dipped down all the way to -80 units.More news: How to listen to Apple Music on Amazon Fire TV
The Premier League champions are also a point clear of Liverpool at the top of the table and, having not lost to Tottenham since 2016, will be confident of progression in Europe too.
Man United or Barcelona vs.
Former Liverpool goalkeeper Chris Kirkland was delighted by the draw, telling Sky Sports News: "I'd prefer being at home for the second leg but I'm extremely happy". This tie looks like Liverpool all the way. Manchester City and Tottenham Hotspur have never won the Champions League.
"Let's not disrespect Porto because they got to this stage for a reason, but they won't be looking forward to that tie". Mauricio Pochettino's team are a threat on their own, but playing in their spectacular new ground could give them an extra edge.More news: US Prepares to Bar Entry of International Criminal Court Investigators
Bayern Munich boss Niko Kovač insists his side can not compete with Europe's top clubs following their Champions League exit against Liverpool.
City have the greater depth and quality, plus the experience of being at this stage of the competition before, but Spurs are unsafe, and this tie could go all the way to penalties before we know who will face Ajax or Juventus in the semis.
The last time the Premier League had four teams in the quarter-finals, in 2008/09, Barcelona beat the Old Trafford side 2-0 in the final in Rome. The semi-finals start on 30 April and 1 May.More news: Multiple deaths in shooting at Mosque
"It [leaving] will cross his mind without a shadow of a doubt because he's done what he's set out to do went there".